At least 16 COI involved in the UPenn CRISPR CAR-t trial – dont make this too big to fail. There are serious dangers with CRISPR, like it or not.

20/21 people have now died in a related trial. The UPenn CAR-t trial which just reported safety in 3 patients made no reference to that.

Neither did the media.

Their pre-clinical trial also had very inadequate off-target analysis – which according to me is a huge problem.

Here is a list of companies driving this trial.

1.  Novartis
2. Tmunity
3. Incyte
4. Celgene
   
5. Amgen
6. IASOBiotherapeutics
   
7. Simcere
8. Takeda
9. ParkerInstituteforCancerImmunotherap
   
10. Abbvie
11. Poseida
12. Janssen
13. CabalettaBio
14. LEKConsulting
15. Genentech
16. ShanghaiUnicarTherapy